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In-center service · Spectra Optia
Therapeutic plasma exchange
Therapeutic plasma exchange (TPE) at Apeiron Center in Austin filters inflammatory molecules, toxins and harmful antibodies from your plasma on the Terumo Spectra Optia. Choose a low-volume 1-liter session ($3,500) or a full exchange of 1.0 or 1.5 plasma volumes (pricing on consultation). Sessions take about 2 hours.
Price
From $3,500
per session
- Platform
- Terumo Spectra Optia
- Options
- 3 volumes
- Session length
- 2 hours
- Location
- Austin clinic
Overview
What it is
Therapeutic Plasma Exchange (TPE) filters toxins, inflammatory molecules, and harmful antibodies from your plasma. Every session at Apeiron Center runs on the Terumo Spectra Optia, with three volume options: low volume (1 liter), a gentle, tolerance-first session; and full volume at 1.0 or 1.5 plasma volumes, a full therapeutic exchange.
Why it matters
Plasma exchange can reduce circulating inflammatory mediators, antibodies, immune complexes, and some plasma-bound substances. Volume sets the dose: a 1-liter session delivers a measured reduction (about a quarter to a third of circulating plasma-phase targets) with a lower physiologic burden, while a full exchange of 1.0 to 1.5 plasma volumes removes roughly 63–78%. We help you choose the right volume for your goals, biology, and tolerance.
Benefits
Key benefits
Deep detox
Removes harmful substances for a full-body refresh.
Inflammation relief
Lowers chronic inflammation for better health.
Immune boost
Strengthens natural defenses.
Mental clarity
Improves focus and reduces brain fog.
Chronic condition support
Effective for autoimmune and inflammatory disorders.
01 · Your options
One platform. Three volumes, matched to your goal.
From a measured ~25–33% reduction to a full therapeutic reset of ~63–78%, the volume you choose sets the dose. Prices are per session.
01Low volume
1 liter
A gentler, lower-dose session, closer to repeated plasma donation than a full exchange.
$3,500 per session
- Volume
- A fixed 1-liter removal, roughly 0.3–0.4 of your plasma volume
- Reduction per session
- ~25–33% of circulating plasma-phase targets
- Experience
- Lower physiologic burden, with less depletion of proteins, clotting factors, and electrolytes
- Best for
- Sensitive patients, first-time exchange, tolerance assessment, and maintenance between full exchanges
02Full volume
1.0 plasma volume
A full therapeutic exchange: the single plasma volume used in published biological-age studies.
Contact us for pricing
- Volume
- One complete plasma volume, replaced with 5% albumin
- Reduction per session
- ~63% of circulating plasma-phase targets
- Experience
- A greater physiologic reset, with session-specific hemodynamic and calcium monitoring
- Best for
- Full-dose therapeutic intent: longevity protocols, autoimmune disease, heavy burden reduction, hyperviscosity
03Full volume
1.5 plasma volumes
An extended full exchange for the deepest available per-session reduction.
Contact us for pricing
- Volume
- An extended exchange of 1½ plasma volumes, replaced with 5% albumin
- Reduction per session
- ~78% of circulating plasma-phase targets
- Experience
- A greater physiologic reset, with session-specific hemodynamic and calcium monitoring
- Best for
- Full-dose therapeutic intent: longevity protocols, autoimmune disease, heavy burden reduction, hyperviscosity
Not sure which volume fits? Get started Or call 512-522-0966.
02 · The math of exchange
Why volume matters, and what it means for your body.
Low volume · 1 liter~25–33%
Of circulating plasma-phase substances removed per session.
Full volume · 1.0 plasma volume~63%
Of circulating plasma-phase substances removed per session.
Full volume · 1.5 plasma volumes~78%
Of circulating plasma-phase substances removed per session.
The curve of diminishing returns.
Think of your plasma like a glass of diluted tea. The first pour of clean water dilutes it dramatically. The second pour dilutes it less. The third, less still.
Moving from nothing to one full plasma volume produces the largest drop in circulating substances. Each additional fraction removes progressively less, so the dose isn’t just a number; it’s a curve.
This is why a 1-liter session is not simply “half” of a full exchange. It’s a meaningfully different intervention with different biological consequences: gentler, yes, but also narrower in what it can accomplish clinically.
Figures assume a one-compartment intravascular target and reflect the classical continuous-flow exchange model. Real-world outcomes depend on molecular size, tissue redistribution, and resynthesis rates.
03 · Which option is yours
Your goal determines the dose.
Full volume preferred
Preventive longevity
Published biological-age studies used one full plasma volume with 5% albumin, sometimes combined with low-dose IVIG. A 1.0 plasma-volume exchange delivers the protocol studied in the research.
Full volume preferred
PFAS and forever chemicals
Full-volume exchange removes a substantially greater fraction of circulating protein-bound PFAS per session than low-volume plasma removal, delivering deeper burden reduction.
Full volume preferred
Heavy metals
Chelation remains primary therapy. When plasma exchange is used as an adjunct, full-dose exchange is mechanistically aligned with maximal circulating removal in a single session.
Full volume preferred
Microplastics and nanoplastics
Evidence is emerging and investigational. When exchange is pursued, a full-volume exchange offers the greatest per-session reduction of circulating particles.
Full volume required
Autoimmune or inflammatory disease
Conditions with high antibody burden, hyperviscosity, cryoglobulins, or ASFA-recognized indications require the full therapeutic dose. Fractional removal is likely to under-treat these mechanisms.
Full volume required
Hyperviscosity, cryoglobulins, paraproteins
These are classic intravascular plasma-protein problems where rapid plasma removal is mechanistically aligned. Only full exchange produces the reduction these conditions require.
Low volume preferred
Frail, sensitive, or low-reserve
Lower body weight, dysautonomia, chemical sensitivity, older age, or a history of procedure intolerance all favor the gentler option. The smaller perturbation reduces risks of fatigue, calcium symptoms, or hemodynamic stress.
Low volume preferred
Tolerance assessment
If you're considering a future full exchange but want to understand how your body responds first, the 1-liter option is an ideal proving ground: we can assess vascular access, citrate tolerance, and post-procedure recovery before escalating.
Low volume preferred
Maintenance after an initial exchange
Some patients pair one or two full-volume exchanges with a maintenance schedule of low-volume sessions. This staged approach preserves the initial reset while minimizing cumulative depletion.
Case by case · often full volume
Severe refractory neuroimmune Lyme
Plasma exchange is not antimicrobial therapy. It is occasionally used as rescue therapy for severe presentations that resemble GBS or autoimmune neuropathy. Antibiotics remain central.
Low volume if mild · full volume if severe
Mold illness and CIRS-like syndromes
Evidence for mycotoxin removal by plasma exchange is weak. Framed honestly, TPE may reduce some circulating inflammatory mediators, but source control, exposure cessation, and downstream support remain foundational.
Discuss with your clinician
Not sure where you fit
Your history, goals, biomarkers, and tolerance for physiologic change all inform the right starting point. This is exactly the conversation we begin in consultation.
04 · Patient profiles
Two approaches, each with its own rhythm.
Low volume · 1 liter
The measured optimizer
Proportional, iterative, and tolerance-first.
- Values gradual change over dramatic intervention.
- Prefers lower fluid, electrolyte, and protein perturbation.
- Is exploring plasma exchange cautiously for the first time.
- Is moving from a full exchange into a maintenance rhythm.
- Is frail, dysautonomic, chemically sensitive, or recovering reserve.
- Wants to understand how their body responds before escalating.
Full volume · 1.0 or 1.5 plasma volumes
The comprehensive reset
Full-dose, evidence-aligned, research-grade.
- Wants the intervention that matches published longevity trials directly.
- Is pursuing the deepest available per-session reduction of PFAS or heavy-metal burden.
- Has a recognized autoimmune or inflammatory indication where dose matters.
- Presents with high antibody, immune-complex, or inflammatory burden.
- Has hyperviscosity, cryoglobulinemia, or paraprotein disease.
- Is prepared for closer monitoring of calcium, proteins, and coagulation.
- Is comfortable with the greater physiologic perturbation of a full exchange.
What to expect
The experience
- Session length
- 2 hours
- Where
- Our Austin clinic, 919 Congress Ave #525
Relax in a plush chair in our medical spa-like environment for a 2-hour session.
The Spectra Optia gently filters your plasma via IV access while you read or rest.
Our expert team monitors your comfort and safety.
Stay hydrated and follow pre-treatment guidelines for optimal results.
Who it’s for
Especially important for
- Individuals with chronic health conditions or autoimmune diseases.
- Patients preparing for or recovering from surgery.
- Those seeking performance optimization.
How we frame the science
Evidence, honestly framed
Plasmapheresis vs. plasma exchange: the distinction matters.
These terms are often used interchangeably, but they are not identical. Plasmapheresis describes the process of obtaining plasma from blood. Plasma exchange specifically means removing plasma and replacing it with a substitute fluid. Every option at our center runs on the Spectra Optia, a platform indicated for therapeutic plasma exchange; the volume you choose sets the dose.
On longevity claims: honest framing.
Early human studies using 1-plasma-volume exchange with 5% albumin have shown encouraging shifts in biological-age biomarkers and inflammatory markers. These are real signals worth discussing, but the evidence remains biomarker-focused, small-scale, and early. We present plasma exchange as a health-optimization intervention with evolving evidence, not a proven anti-aging treatment.
On PFAS, heavy metals, and environmental burden.
Plasma exchange can reduce circulating inflammatory mediators, antibodies, immune complexes, and some plasma-bound substances. For PFAS specifically, full-volume exchange produces a meaningfully larger per-session reduction than low-volume plasma removal. For heavy metals, chelation remains primary; plasma exchange serves as an adjunct. Benefit depends on whether the relevant burden is actually in the plasma at the time of the procedure, and whether the source has been addressed.
On the right first choice.
Our decision rule is simple. When therapeutic-dose mediator removal matters most, including longevity protocols, PFAS reduction, heavy-metal adjunctive care, microplastics research, and recognized disease indications, we recommend a full-volume exchange. When proportionality and tolerability matter most, for sensitive patients, tolerance assessment, and maintenance schedules, we begin with low volume. The choice is not a preference. It is a clinical match between your goals and the dose curve.
On monitoring.
Every procedure at Apeiron Center is accompanied by thorough baseline screening: CBC, comprehensive metabolic panel, albumin, total protein, fibrinogen, coagulation studies, ionized calcium, immunoglobulins where serial procedures are planned, and condition-specific markers. Full-volume exchanges also include session-specific hemodynamic and calcium monitoring.
A note on scope
The Spectra Optia is indicated for therapeutic plasma exchange. Applications beyond FDA-cleared indications, including longevity optimization, environmental toxin reduction, and off-label use for complex chronic conditions, are discussed with each patient as investigational or off-label where appropriate. Informed consent is central to everything we do.
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Begin with the right conversation
Choosing a volume is a clinical decision that depends on your goals, history, and biology. Book a session (from $3,500 per session), or get started and we'll help you decide, carefully.
Prefer to talk? Call 512-522-0966